Arizona Cardinals
San Francisco 49ers
Kickoff: 4:05 PM
Levi’s Stadium, Santa Clara
Match Facts
- League
- National Football League
- Week
- Week 3
- Date
- 09/27/2026
- Venue
- Levi’s Stadium
Sunday, September 27 puts the NFC West at the heart of the football weekend when San Francisco welcomes Arizona for a Week 3 meeting at Levi’s Stadium in Santa Clara. The 49ers host off a 12-5 season, the Cardinals arrive off a 3-14 year, and the two sides met twice last season with San Francisco taking the games 16-15 and 41-22. It is the kind of divisional afternoon that fills a building and sets a tone for the weeks ahead.
The gap between the sides last season was wide – 12 wins to three and 437 points scored to 355 – and Arizona arrives on a five-game losing streak while San Francisco closed with three wins in five.
Head-to-Head
| Date | Result | Venue |
|---|---|---|
| 11/16/2025 | San Francisco 49ers 41 @ 22 Arizona Cardinals | at Arizona Cardinals |
| 09/21/2025 | Arizona Cardinals 15 @ 16 San Francisco 49ers | Levi’s Stadium, Santa Clara |
Season form
San Francisco finished 2025/26 with a 12-5 record and a 70.6 win percentage, while Arizona closed at 3-14. The 49ers’ last five outings ran L-W-L-W-W, featuring wins over Philadelphia (23-19), Chicago (42-38) and Indianapolis (48-27), with both losses coming against Seattle. Arizona spent the tail of its year in a five-game slide, dropping games to the Rams twice, the Bengals, the Falcons and the Texans.
Offense vs defense
San Francisco’s offense posted 4,571 passing yards and 2,000 rushing yards with 36 passing touchdowns and 15 rushing scores, against an Arizona defense that allowed 3,130 through the air and 1,929 on the ground. Arizona countered with 3,955 passing yards and 1,583 rushing yards, 29 touchdown passes and nine rushing touchdowns, while the 49ers’ defense gave up 3,738 passing yards and 1,837 rushing. The 49ers also protected their passer better, surrendering 31 sacks to the Cardinals’ 59, and San Francisco converted field goals at 92.3 percent to Arizona’s 75.8.
Head-to-head history
The two NFC West neighbors met twice in 2025/26. In Week 3 at Levi’s Stadium, San Francisco edged Arizona 16-15, and in Week 11 at Arizona the 49ers won again, 41-22. This Sunday’s Week 3 game brings them back to the same Santa Clara venue where the 2025 meeting was decided.
Last meeting
The most recent meeting came in Week 11 of last season, when San Francisco traveled to Arizona and came away with a 41-22 win. The 49ers closed the season at 12-5, while the Cardinals finished 3-14. The Week 3 rematch hands the home field back to San Francisco.
When and where do the Arizona Cardinals play the San Francisco 49ers in Week 3?
The two teams meet on Sunday, September 27 at Levi’s Stadium in Santa Clara for an afternoon kickoff.
What were the Cardinals’ and 49ers’ records last season?
San Francisco finished the 2025/26 season at 12-5, while Arizona ended the year at 3-14. Both sides play in the NFC West.
Who won the most recent game between Arizona and San Francisco?
San Francisco won the last meeting, beating Arizona 41-22 in Week 11 of last season at Arizona.
How did each team close out last season?
San Francisco’s final five games went L-W-L-W-W, while Arizona lost all five of its last outings.
What division do the Cardinals and 49ers play in?
Both teams play in the NFC West of the National Football League, alongside the Los Angeles Rams and the Seattle Seahawks.
Next Match
Week 3 · Levi’s Stadium · Arizona Cardinals vs San Francisco 49ers
Regular Season NFL match-ups by week 272 games ▾
▼ Week 1 16 games
|
Thu, Sep 10 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Mon, Sep 14 |
|
Date TBD |
▼ Week 2 16 games
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Thu, Sep 17 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Mon, Sep 21 |
▼ Week 3 16 games
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Thu, Sep 24 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Mon, Sep 28 |
▼ Week 4 16 games
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Thu, Oct 1 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Mon, Oct 5 |
▼ Week 5 15 games
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Thu, Oct 8 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Mon, Oct 12 |
▼ Week 6 14 games
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Thu, Oct 15 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Mon, Oct 19 |
▼ Week 7 14 games
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Thu, Oct 22 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Sun, Oct 25 |
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Mon, Oct 26 |
▼ Week 8 14 games
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Thu, Oct 29 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Mon, Nov 2 |
▼ Week 9 15 games
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Thu, Nov 5 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Mon, Nov 9 |
▼ Week 10 14 games
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Thu, Nov 12 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Mon, Nov 16 |
▼ Week 11 13 games
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Thu, Nov 19 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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Mon, Nov 23 |
▼ Week 12 16 games
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Wed, Nov 25 |
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Thu, Nov 26 |
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Thu, Nov 26 |
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Thu, Nov 26 |
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Fri, Nov 27 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Sun, Nov 29 |
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Mon, Nov 30 |
▼ Week 13 14 games
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Thu, Dec 3 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Mon, Dec 7 |
▼ Week 14 15 games
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Thu, Dec 10 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Mon, Dec 14 |
▼ Week 15 16 games
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Thu, Dec 17 |
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Sat, Dec 19 |
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Sat, Dec 19 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Mon, Dec 21 |
▼ Week 16 16 games
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Thu, Dec 24 |
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Fri, Dec 25 |
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Fri, Dec 25 |
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Fri, Dec 25 |
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Sat, Dec 26 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Mon, Dec 28 |
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Date TBD |
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Date TBD |
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Date TBD |
▼ Week 17 16 games
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Thu, Dec 31 |
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Sat, Jan 2 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Mon, Jan 4 |
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Date TBD |
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Date TBD |
▼ Week 18 16 games
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Sun, Jan 10 |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |
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Date TBD |