2025 NFL Week 2 Odds & Betting Lines

The NFL’s opening week 1 delivered a thrilling start, with jaw-dropping performances from the Eagles, Cowboys, and Chiefs, alongside unexpected twists from the Patriots and Buccaneers. With NFL Week 2 on the horizon, anticipation is building for another round of explosive football action.

In this preview, we’ll break down the most anticipated matchups and offer you the insights you need to stay ahead of the game. Whether you’re a seasoned bettor or a football fanatic, Bovada has all the NFL odds you need for Week 2 – let’s go.

LATEST ODDS

Latest NFL odds at Bovada!

2024 NFL week 1

Buffalo Bills (+105) at Miami Dolphins (-125)

The Bills-Dolphins rivalry is legendary, and this season’s clash promises to be another unforgettable chapter. This season’s versions of both teams are close to evenly matched, with two All-Pro quarterbacks Josh Allen and Tua Tagovailoa leading the way.

The Dolphins rode an 80-yard touchdown reception by WR Tyreek Hill to launch a comeback from 10 points down in their game against Jacksonville. In all, Tagovailoa threw for over 330 yards. The Bills, meanwhile, had to scrape by to secure a ‘W’ against Arizona, despite being 7-point favorites heading into the game.

Both teams won their Week 1 games, but neither one covered the spread. Buffalo has the Fins’ number lately, winning 11 out of their last 12 head-to-head matchups.

Players of the Over/Under NFL odds might like the over (currently 50.5) for this one too – three out of the past four meetings between the two teams have finished with 60+ points total.

Check out the Bills-Dolphins event page regularly for updated lines and every way to play this Thursday Night Football battle.

Tampa Bay Buccaneers (+235) at Detroit Lions (-290)

After their intense NFC Divisional Round battle, where the Lions edged out the Bucs 31-23, Tampa Bay is hungry for redemption. While many are picking Detroit to go far again this year and they seem like the stronger team, the Bucs might be looking to avenge that loss.

Detroit kicked off its season by covering the spread (by a mere 0.5 though) in a win over the LA Rams. They needed overtime to do it, however.

With Lions’ QB Jared Goff throwing for just over 200 yards and one interception, betting fans might be surprised that the NFL odds favor him over Bucs’ QB Baker Mayfield, who’s fresh off a 289-yard, 4-TD performance in Week 1, hooking up regularly with his veteran receivers Mike Evans and Chris Godwin.

In that playoff loss last season, Mayfield threw for close to 350 yards but he had two crucial INTs. If he can minimize the turnovers this weekend, the Bucs could well cover the current +6.5 spread.

You’ll find all the props and lines for Tampa Bay – Detroit, along with all the other games, at Bovada.

Cincinnati Bengals (+205) at Kansas City Chiefs (-245)

In an early season shocker, the Cincinnati Bengals lost 16-100 to New England in Week 1.

With a healthy Joe Burrow at QB, the Bengals were expected to get off to a solid start to the season. Instead, with three turnovers and only 164 yards passing, Cincy couldn’t cover the -7.5 spread and they were well under the Totals of 41. Ja’Marr Chase, the Bengals’ WR, is still unhappy about his contract, as such, his uncertain playing and practice status might be impacting the team.

The Chiefs could turn this one into a rout. They’re coming off a longer rest, having played in the Thursday night opener. They’ve also got the legendary Patrick Mahomes at QB, with a speedy new target in rookie receiver Xavier Worthy. The young WR picked up two touchdowns in his debut game, one on the ground and one receiving.

KC is 13-6-1 in their last 20 against the spread. Oh, and they’re the reigning Super Bowl champs, so that helps. The only apparent upside in this game for Bengals? Burrow is 3-1 in his career against Mahomes and the Chiefs.

Whether that’s the X factor for you, or if you think the Chiefs will take complete control, check out all the action and ways to play on the Bengals-Chiefs event page.

Chicago Bears (+255) at Houston Texans (-310)

The Texans, coming off a strong season, have high expectations this year. But the Bears are poised to challenge them, making this matchup a crucial test for both teams.

QB C.J. Stroud scored a great new target in receiver Stefon Diggs in the off-season, and the team added running back Joe Mixon too. Mixon already paid off in Week 1, with 159 yards rushing and a TD.

On the other side, Bears’ QB Caleb Williams, the #1 pick of the off-season and already starting for the team, had a mediocre start to his career in Week 1, finishing with just 93 yards passing.

The Texans’ D might not be any more welcoming for the rookie. In their Week 1 win over the Colts, they held QB Anthony Richardson to just 9 completions.

The spread is currently -7 in favor of Houston, and you can find it and plenty of other action at the Bears-Texans betting page at Bovada.

Atlanta Falcons (+180) at Philadelphia Eagles (-220)

With high hopes for their new acquisitions, including Kirk Cousins and rookie Michael Penix Jr., the Falcons are ready to make a statement against the formidable Eagles, who are coming off a solid Week 1 performance.

But the Steelers’ defense made sure to put a lid on that excitement. Cousins threw for just 155 yards and two picks in the game, and highly touted RB Bijan Robinson managed less than 70 yards on the ground.

The bright side for Falcons fans and bettors is the Eagles’ run defense, which gave up 163 yards in their first game of the year against the Packers.

On the offensive side of the ball, Philly looks much better. Fresh new Eagle, running back Saquon Barkley, made an immediate impact with 3 TDs in that game. And A.J. Brown picked up where he left off last season, with 10 catches for 119 yards and a TD.

With a fired-up home crowd for the team’s home opener, the Eagles could soar in this battle of the birds.

All the Falcons vs. Eagles bets you need are ready to play at Bovada.

Get in on the Action:

*Odds subject to change

Place your Week 2 NFL bets at Bovada now and get into live betting on game day. Every prop, parlay, spread, moneyline, and total you could want, is now, right at your fingertips.

Take advantage of the Sports Welcome Bonus which gives you an edge from the minute you sign up with Bovada. Plus you’ll score an even bigger bonus when you deposit with crypto. Don’t miss out—make your moves and maximize your winnings with Bovada.

JOIN NOW

Sign up to Bovada today