Week 9 reshaped the top of the rankings, again. USC handed Ohio State a 30-18 loss, Georgia controlled Florida 27-8, and Miami survived North Carolina 38-35. Iowa blanked ranked Wisconsin 30-0, Syracuse upset SMU 30-27, and Iowa State stunned Oklahoma State 51-49, helping send four new teams into the AP Top 25.
Week 10 may be the most exciting of the regular season. Six ranked-versus-ranked games: No. 1 Miami visits No. 4 Notre Dame, No. 2 Georgia travels to No. 12 Ole Miss, and the first top-10 matchup in the history of the “Holy War” rivalry: No. 7 BYU at No. 3 Utah.
Here’s our preview of the Week 10 college football odds, along with the latest AP Top 25 and college football betting trends.
College Football Week 10 Games to Watch
Saturday, Nov. 7: No. 7 BYU at No. 3 Utah – 12 p.m. ET, ABC
- Spread: Utah -5
- Moneyline: BYU +167, Utah -195
- Total: 49
The first top-10 matchup in “Holy War” history also carries Big 12 and playoff weight. Utah is 8-0 after Devon Dampier directed a 49-25 win at Cincinnati, while BYU improved to 7-1 by holding off Arizona State 27-20. The Utes’ speed on defense makes Bear Bachmeier’s protection the central matchup, especially if BYU running back LJ Martin remains limited after missing four games.
Saturday, Nov. 7: No. 10 Texas at No. 19 Missouri – 12 p.m. ET, ESPN
- Spread: Missouri +2.5 (-103)
- Moneyline: Texas -140, Missouri +120
- Total: 43
Texas responded to its loss at Ole Miss by beating Mississippi State 31-3, its best defensive performance of the season. Missouri also rebounded, defeating Arkansas 34-10. The matchup and spread depend on whether Missouri can create manageable downs for quarterback Matt Zollers against a Texas front that just smothered the Bulldogs. A low total reflects two defenses that have been more reliable than either passing game.
Saturday, Nov. 7: No. 9 Alabama at No. 15 LSU – 3:30 p.m. ET, ABC
- Spread: LSU -5.5 (-115)
- Moneyline: Alabama +195, LSU -235
- Total: 52.5
Both teams enter rested after a bye for a massive SEC matchup between two 6-2 teams. While LSU gets the home-field edge, Alabama hopes to return several contributors, including receiver Ryan Coleman-Williams and cornerback Zabien Brown. LSU quarterback Sam Leavitt’s ability to punish the Tide’s pass-rush pressure could decide whether the Tigers justify a spread larger than a field goal.
Saturday, Nov. 7: Oregon at No. 11 Ohio State – 3:30 p.m. ET, CBS
- Spread: Ohio State -8
- Moneyline: Oregon +260, Ohio State -320
- Total: 46.5
Ohio State must regroup after its nine-spot drop in the AP poll, but they’ll have to rely on backup quarterback Luke Fahey again with Julian Sayin still sidelined. Fahey threw for 260 yards in his debut, but much of it came after USC had taken control. The good news is Oregon is also using a backup QB, Dylan Raiola, after Dante Moore’s season-ending injury. The Buckeyes’ pass defense and Oregon’s ability to protect Raiola are the clearest reasons for the modest total.
Saturday, Nov. 7: No. 2 Georgia at No. 12 Ole Miss – 7:30 p.m. ET, ABC
- Spread: Ole Miss +3.5 (-108)
- Moneyline: Georgia -180, Ole Miss +155
- Total: 56.5
Georgia allowed only eight points against Florida, while Ole Miss followed its road win over Texas with a 45-15 rout of Auburn. That could mean QB Gunner Stockton will need to produce more to keep the Bulldogs ahead of the Rebels. That said, while Ole Miss quarterback Trinidad Chambliss is active, the Rebels may be without leading running back Kewan Lacy – he’s listed as doubtful.
Saturday, Nov. 7: No. 1 Miami at No. 4 Notre Dame – 7:30 p.m. ET, NBC
- Spread: Notre Dame -5.5 (-115)
- Moneyline: Miami +185, Notre Dame -225
- Total: 57.5
The nation’s No. 1 team is an underdog because Notre Dame pairs an elite defense with a balanced offense. Miami quarterback Darian Mensah has completed 80.7 percent of his passes for 2,425 yards, 25 touchdowns and one interception, but the Hurricanes needed a late escape at North Carolina. Notre Dame allows 236.1 yards per game and has surrendered only 13.4 points per contest, creating Miami’s toughest matchup of the season.
Key Players to Watch in College Football Week 10
- Darian Mensah, QB, Miami: His accuracy and one-interception season meet Notre Dame’s top-ranked total defense.
- Luke Fahey, QB, Ohio State: The freshman must avoid obvious passing downs after Ohio State committed 11 penalties in his first start.
- Trinidad Chambliss, QB, Ole Miss: A doubtful Kewan Lacy would make Chambliss even more important against Georgia’s disciplined front.
College Football Week 10 Betting Trends
- Favorites finished Week 9 at 31-23 ATS (57.4%), while 11 underdogs won outright.
- Unders went 31-25 in Week 9, cashing in 55.4% of completed games despite two totals reaching 100 points.
- In the six Week 9 games we’ve previewed here, the listed home teams went 5-1 ATS and the over finished 4-2.
- Five unranked teams defeated AP Top 25 opponents outright in Week 9: USC, Syracuse, Oregon, Iowa State and Iowa.
- Miami is the No. 1 team but a +185 moneyline underdog. Notre Dame is 5-0 at home this season, while Miami is making its first trip to a current top-five opponent.
- Four ranked road teams are underdogs on this slate: BYU, Alabama, Miami and Kentucky. Each is receiving at least five points.
AP Top 25 – Week 10
| RK | TEAM | REC | PTS | TREND |
| 1 | Miami (62) | 8-0 | 1740 | – |
| 2 | Georgia (7) | 7-1 | 1648 | ↑1 |
| 3 | Utah (1) | 8-0 | 1540 | ↑3 |
| 4 | Notre Dame | 7-1 | 1476 | ↑1 |
| 5 | UCLA | 8-0 | 1473 | ↑2 |
| 6 | Indiana | 8-1 | 1446 | ↓2 |
| 7 | BYU | 7-1 | 1358 | ↑1 |
| 8 | Kentucky | 7-1 | 1253 | ↑1 |
| 9 | Alabama | 6-2 | 1107 | ↑1 |
| 10 | Texas | 6-2 | 1057 | ↑1 |
| 11 | Ohio State | 6-2 | 1049 | ↓9 |
| 12 | Ole Miss | 6-2 | 953 | – |
| 13 | Texas Tech | 7-1 | 931 | – |
| 14 | Wake Forest | 7-1 | 898 | – |
| 15 | LSU | 6-2 | 814 | – |
| 16 | Tennessee | 6-2 | 719 | – |
| 17 | Houston | 6-2 | 590 | ↑1 |
| 18 | USC | 7-2 | 539 | NR |
| 19 | Missouri | 6-2 | 475 | ↑4 |
| 20 | Boise State | 7-1 | 451 | – |
| 21 | Iowa | 6-2 | 401 | NR |
| 22 | New Mexico | 7-1 | 179 | NR |
| 23 | South Carolina | 5-3 | 163 | NR |
| 24 | Arizona | 6-2 | 154 | ↓2 |
| 25 | Florida | 5-3 | 94 | ↓8 |
College Football Week 10 FAQs
When does college football Week 10 start?
Week 10 begins Wednesday, November 4, with MAC games and continues through Saturday, November 7.
What is the biggest game in Week 10?
No. 1 Miami at No. 4 Notre Dame is the highest-ranked matchup. No. 2 Georgia at No. 12 Ole Miss and No. 7 BYU at No. 3 Utah also carry major conference and playoff consequences.
How many ranked matchups are in Week 10?
Six games feature two AP-ranked teams: BYU-Utah, Texas-Missouri, Alabama-LSU, Kentucky-Tennessee, Georgia-Ole Miss, and Miami-Notre Dame.
Where can I bet on college football Week 10?
You can find updated college football odds at Bovada. Same Game Parlays also provide 3x the reward points for certain four-or-more same-game picks.