The Ultimate Fighting Championship is back in Las Vegas for UFC 322, and Sin City is providing a card packed with elite matchups and championship implications. The event features a welterweight showdown between knockout artists Jack Della Maddalena and the reigning lightweight king, Islam Makhachev, who moves up in weight class to face championship glory. In the Co-main event, Valentina Shevchenko faces Weili Zhang, a bout that could determine the best pound-for-pound woman in the sport.
With proven veterans and surging prospects throughout the lineup, UFC 322 promises another night of action that could reshape multiple divisions. Let’s break down the UFC 322 odds before the action starts on November 15, 2025.
View the latest odds at Bovada
Jack Della Maddalena vs. Islam Makhachev (Welterweight Main Event)
- Della Maddalena +205
- Makhachev -245
Records:
- Jack Della Maddalena (18-2-0)
- Islam Makhachev (27-1-0)
Makhachev’s dominance at lightweight has reached rarified air after defending the 155-pound title multiple times, improving his striking skills and blending it with suffocating defense, and now aiming for two-division greatness against Della Maddalena.
Maddalena is a pure striker with knockout power; his boxing is among the crispest in MMA, with combinations and body work reminiscent of UFC legend Nick Diaz. Makhachev’s well-rounded mastery has him favored, but he’ll have to keep Maddalena at bay and take him to the ground when he finds an opening.
At +205, Della Maddalena offers underdog value for bettors chasing a knockout upset, but over five rounds, Makhachev’s pressure and precision make him a justifiable favorite.
Valentina Shevchenko vs. Weili Zhang (Women’s Flyweight Co-Main)
- Shevchenko -135
- Zhang +115
Records:
- Valentina Shevchenko (25-4-1)
- Weili Zhang (26-3-0)
We finally have the dream matchup we’ve been waiting for. The former flyweight queen faces the reigning strawweight champion in a superfight for legacy.
Shevchenko’s tactical brilliance and counter-striking remain elite, but at 37, she’s fighting a younger, faster opponent in Zhang, who boasts relentless pressure, cardio, and clinch strength. She’s a +115 underdog, but a live dog who would only be an upset on paper.
Still, Shevchenko’s composure and accuracy could be decisive if she keeps Zhang at a distance. The total of 4.5 rounds (-260 Over) suggests a chess match more than a brawl.
Sean Brady vs. Michael Morales (Welterweight)
- Brady -140
- Morales +120
Records:
- Sean Brady (18-1-0)
- Michael Morales (18-0-0)
This fight could crown the next welterweight title contender. Brady, one of the UFC’s strongest grapplers, meets the undefeated Ecuadorian striker Morales, who continues to pass every test.
Brady’s lone loss came to Belal Muhammad, and since then, he’s doubled down on his wrestling-heavy game plan. Morales is a lightning-fast striker, but could struggle with Brady’s ground control. Oddsmakers lean slightly toward Brady, whose ground dominance often neutralizes opponents.
Expect early takedown attempts from Brady and late-fight fireworks if Morales keeps it standing.
Leon Edwards vs. Carlos Prates (Welterweight)
- Edwards +168
- Prates -198
Records:
- Leon Edwards (22-5-0, 1 NC)
- Carlos Prates (22-7-0)
Former welterweight champion Leon Edwards returns against Brazil’s knockout specialist Carlos Prates, who’s quietly become one of the division’s most feared finishers.
Edwards brings elite experience and one of the smoothest defensive striking arsenals in MMA. But Prates’ has three straight first-round finishes and has oddsmakers leaning his way.
At nearly 2-to-1 underdog odds, Edwards could surprise, but if Prates maintains an up-tempo pace, this could be a torch-passing moment.
Beneil Dariush vs. Benoit Saint-Denis (Lightweight)
- Dariush +165
- Saint-Denis -195
Records:
- Beneil Dariush (23-6-1)
- Benoit Saint-Denis (15-3-0, 1 NC)
This lightweight bout epitomizes grit vs. grit. Dariush is a resilient, technically sound, and battle-tested vet. Meanwhile, Saint-Denis continues to bulldoze through ranked competition, earning five straight stoppages heading into UFC 322.
Oddsmakers see momentum favoring the Frenchman, but Dariush’s experience in high-pressure moments can’t be ignored. Saint-Denis’ relentless style could leave openings for counter-submissions if he overcommits. The under 1.5 rounds (+125) line indicates bookmakers expect violence early, and with both fighters known to finish fights early, they’re probably right.
Bo Nickal vs. Rodolfo Vieira (Middleweight)
- Nickal -220
- Vieira +180
Records:
- Bo Nickal (7-1-0)
- Rodolfo Vieira (11-3-0)
Two of the best grapplers in the sport meet in a stylistic dream fight. Nickal’s NCAA wrestling pedigree meets Vieira’s world-champion jiu-jitsu. Despite both fighters’ ground prowess, Nickal’s pace and control put the odds in his favor. Expect quick scrambles which could lead to an early finish.
Roman Kopylov vs. Gregory Rodrigues (Middleweight)
- Rodrigues -160
- Kopylov +135
Records:
- Roman Kopylov (14-4-0)
- Gregory Rodrigues (17-6-0)
“Robocop” Rodrigues looks to continue his resurgence against the dangerous Kopylov, who’s known for sharp counter-strikes and durability. Rodrigues’ improved striking and durability since his 2024 setbacks make him a slight favorite, but Kopylov’s body attacks and late-round pressure could test his endurance.
Erin Blanchfield vs. Tracy Cortez (Women’s Flyweight)
- Blanchfield -240
- Cortez +200
Records:
- Erin Blanchfield (13-2-0)
- Tracy Cortez (12-2-0)
A pivotal matchup in the women’s flyweight division. Blanchfield’s relentless wrestling and grappling have her pegged as the next title contender, while Cortez’s boxing and takedown defense make her a potential spoiler. The odds tell the story – Blanchfield is the rightful favorite, but Cortez’s defensive fundamentals could stretch this to the scorecards.