Oh you thought holiday football was over? We hope you enjoy the turkey, stuffing, and the three 2025 Thanksgiving Day Games on Thursday because another 13 games left on the schedule for Week 13 – starting with a matchup on Friday.
Some of the squads who went on surprising runs in the first half of the season are starting to come back to earth. Meanwhile, some of the struggling squads are beginning to gain experience, get healthy, and make for more competitive matchups. Where does that leave us? With a lot of parity and a lot of NFL odds that keep us second-guessing.
Check out the rest of the NFL Week 13 odds and see the best matchups below.
View the latest NFL odds at Bovada!
Friday Afternoon Game
Chicago Bears (8-3) at Philadelphia Eagles (8-3)
- Start: November 28 at 3:00 p.m. ET on FOX
- Spread: Eagles -7.0
- Moneyline: Eagles -310, Bears +255
- Total: 44.5
The Bears are rolling and it’s been great for Chicago bettors. They’ve won four straight, with each going down to the wire, and have been a profitable 7-4 against the spread (ATS). Now they face arguably their biggest measuring stick all year in Philly. The +7 spread is the largest they’ve been afforded all year, it could be because the Eagles are energized and angry after giving up a 21-0 lead in a loss to Dallas. Or it could be because the struggling Eagles offense could finally breathe against a Bears defense that ranks 27th in points against (26.5).
Sunday Games
Houston Texans (6-5) at Indianapolis Colts (8-3)
- Start: November 30 at 1:00 p.m. ET on CBS
- Spread: Colts -4.5
- Moneyline: Colts -225, Texans +185
- Total: 44.5
The Colts are in a dangerous place.
Before the November 4th NFL trade deadline they were the most efficient team in football and Daniel Jones looked like the answer to their Super Bowl aspirations. So much so that they traded two first-round picks for shutdown corner in Sauce Gardner.
Then reality set in.
Teams started keying on the engine of the Colts offense – running back Jonathan Taylor – and put the pressure on Jones to carry the team to victory. The result is a 1-2 record straight up (SU) and an 0-3 record ATS over the last three weeks. Now with Houston surging, and Jacksonville still in the mix, Indy could be in a position where they don’t even make the playoffs after giving away their future.
Houston enters Indy riding a three-game win streak and the possibility of having QB CJ Stroud back under center. Their defense remains one of the best in the NFL, ranking second in points against (16.5) while holding opponents to under 100 yards rushing per game. They have the personnel to once again make the Colts a one-dimensional offense.
Los Angeles Rams (7-4) at Carolina Panthers (6-6)
- Start: November 30 at 1:00 p.m. ET on FOX
- Spread: Rams -10.5
- Moneyline: Rams -550, Panthers +400
- Total: 45
The Panthers might be the most frustrating team in the NFL. They’ve been blown out by Buffalo (40–9), then upset Green Bay (16–13); lost to New Orleans (17–7), hung 30 on Atlanta, then followed it by scoring nine in a loss to San Francisco. Which Carolina squad shows up against one of the league’s best?
Oddsmakers clearly see them as NFC South pretenders, hanging a +10.5 homedog spread on Carolina. If they keep this close, it’ll be because of their defense – the one reliably steady unit, allowing just 22.4 points per game.
Buffalo Bills (7-4) at Pittsburgh Steelers (6-5)
- Start: November 30 at 4:25 p.m. ET on CBS
- Spread: Bills -3.5
- Moneyline: Bills -200, Steelers +170
- Total: 48.0
What direction are the Steelers going in? They had a stranglehold on the AFC North but they’ve watched it dwindle with inconsistent play on both sides of the ball. Last week, they surprisingly had one of their better offensive outings in a loss to Chicago despite having to start backup QB Mason Rudolph. Unfortunately, their defense didn’t’ step up and they lost 31-28.
Steelers coach Mike Tomlin has said that he’s optimistic about Aaron Rodgers’ returns from a fractured wrist on his non-throwing arm, but will that be enough against Buffalo? Oddsmakers have made the Bills just 3.5 favorites, likely due to how badly reigning MVP Josh Allen played against Houston. Allen just hasn’t looked comfortable the last three weeks, throwing five interceptions with five touchdowns.
*Odds subject to change
All NFL Matches in Week 13
| Date | Time (ET) | Team A | Team B | Location |
|---|---|---|---|---|
| Thursday, November 27, 2025 | 1:00 PM | Green Bay Packers | Detroit Lions | Ford Field, Detroit, MI |
| Thursday, November 27, 2025 | 4:30 PM | Kansas City Chiefs | Dallas Cowboys | AT&T Stadium, Arlington, TX |
| Thursday, November 27, 2025 | 8:20 PM | Cincinnati Bengals | Baltimore Ravens | M&T Bank Stadium, Baltimore, MD |
| Friday, November 28, 2025 | 3:00 PM | Chicago Bears | Philadelphia Eagles | Lincoln Financial Field, Philadelphia, PA |
| Sunday, November 30, 2025 | 1:00 PM | Los Angeles Rams | Carolina Panthers | Bank of America Stadium, Charlotte, NC |
| Sunday, November 30, 2025 | 1:00 PM | San Francisco 49ers | Cleveland Browns | Huntington Bank Stadium, Cleveland, OH |
| Sunday, November 30, 2025 | 1:00 PM | Houston Texans | Indianapolis Colts | Lucas Oil Stadium, Indianapolis, IN |
| Sunday, November 30, 2025 | 1:00 PM | New Orleans Saints | Miami Dolphins | Hard Rock Stadium, Miami Gardens, FL |
| Sunday, November 30, 2025 | 1:00 PM | Atlanta Falcons | New York Jets | MetLife Stadium, East Rutherford, NJ |
| Sunday, November 30, 2025 | 1:00 PM | Arizona Cardinals | Tampa Bay Buccaneers | Raymond James Stadium, Tampa, FL |
| Sunday, November 30, 2025 | 1:00 PM | Jacksonville Jaguars | Tennessee Titans | Nissan Stadium, Nashville, TN |
| Sunday, November 30, 2025 | 4:05 PM | Minnesota Vikings | Seattle Seahawks | Lumen Field, Seattle, WA |
| Sunday, November 30, 2025 | 4:25 PM | Las Vegas Raiders | Los Angeles Chargers | SoFi Stadium, Inglewood, CA |
| Sunday, November 30, 2025 | 4:25 PM | Buffalo Bills | Pittsburgh Steelers | Acrisure Stadium, Pittsburgh, PA |
| Sunday, November 30, 2025 | 8:20 PM | Denver Broncos | Washington Commanders | FedExField, Landover, MD |
| Monday, December 1, 2025 | 8:15 PM | New York Giants | New England Patriots | Gillette Stadium, Foxborough, MA |